Rabies Antibodies in Vaccinated Dogs |
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Authors: | L. Sihvonen K. Kuhnen E. Neuvonen K. Pekkanen |
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Affiliation: | Vaccine and Production Unit and Virology Unit, National Veterinary and Food Research Institute, P.O. Box 368, SF-00231 Helsinki, Finland |
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Abstract: | Forty-seven healthy, owned dogs were vaccinated with Madivak and 85 with Rabisin. Geometric mean titres of 17.40 and 1.03 IU/ml were measured by the rapid immunofluorescent focus inhibition test 30–40 and 350–370 days, respectively, after a single injection. Four out of 130 (3.1%) and 18 out of 106 (17% ) dogs had a titre of less than 0.5 IU/ml in serum 30–40 and 350–370 days after vaccination. Twenty-one dogs (19.8%) had a titre of 0.5 IU/ml 350–370 days after vaccinaton. There was no significant difference in antibody levels between animals vaccinated with Rabisin or Madivak. Our results indicate that a booster is always necessary after a single injection to ensure that all dogs have a lasting antibody titre. |
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Keywords: | immunization protection |
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