Effect of Chronic Furosemide on Salt and Water Intake of Ponies |
| |
| Institution: | 1. Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, Egypt;2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt;3. Department of Molecular Biology, National Research Centre, El Buhouth St., Dokki, Cairo 12622, Egypt;1. Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN, USA;2. Department of Pathobiology and Diagnostic Investigation/Diagnostic Center for Population and Animal Health, Michigan State University, East Lansing, MI, USA;1. ICAR-National Research Center on Equines, Hisar, Haryana, India;2. Division of Veterinary Medicine, Indian Veterinary Research Institute, Izzatnagar, Bareilly, Uttra Pradesh, India;1. Gastroenterology and Liver Services, Bankstown Hospital, Sydney South West Local Health District, Sydney, New South Wales, Australia;2. Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia;3. Department of Histopathology, Douglass Hanly Moir Pathology, Sydney, New South Wales, Australia;4. Faculty of Medicine, The University of Notre Dame, Sydney, New South Wales, Australia;5. Ingham Institute of Applied Medical Research, Sydney, New South Wales, Australia;6. Immunology Division, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia;7. Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Australia |
| |
| Abstract: | Furosemide is used acutely in racehorses and chronically for treatment of edema and congestive heart failure, but the behavioral effects on horses of chronic administration of this drug have not been studied. The objectives of this study were to measure salt and water intake as well as sodium and water losses in ponies treated chronically with furosemide. The salt and water intake of ponies was measured daily for 3 weeks before and 3 weeks during treatment with furosemide at a dose of 0.5 mg/kg/d. Fecal dry matter was measured for 9 days before and during furosemide treatment by collecting a fecal sample from each pony's stall and drying it overnight in a 100°C oven. Urine volume and urine sodium content were measured daily for three consecutive days during pretreatment, treatment, and post-treatment periods so that sodium and water status could be calculated. Sodium chloride intake increased in ponies treated daily with furosemide from 7.9 ± 2.2 (standard error of the mean) to 20.3 ± 2.4 g/d and was significantly higher than control for all weeks of treatment (P < .03). Water intake was also significantly increased from 8.9 ± 1 during the control period to 11 ± 0.7 kg/d during furosemide treatment (P < .001), and the ponies drank more water than they lost. Urine volume and urine sodium concentrations increased significantly during treatment with the diuretic, whereas urinary potassium and calcium concentrations decreased. |
| |
| Keywords: | Horse Salt appetite Water intake Sodium balance Furosemide |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
