首页 | 本学科首页   官方微博 | 高级检索  
     


Detection of two different papillomaviruses within a feline cutaneous squamous cell carcinoma: Case report and review of the literature
Authors:JS Munday  M Dunowska  S De Grey
Affiliation:1. Department of Pathobiology, Institute of Veterinary, Animal and Biomedical Sciences , Massey University , Private Bag 11222, Palmerston North 4442, New Zealand E-mail: j.munday@massey.ac.nz;2. Infectious Diseases, Institute of Veterinary, Animal and Biomedical Sciences , Massey University , Private Bag 11222, Palmerston North 4442, New Zealand;3. Inglewood Veterinary Services Ltd , PO Box 19, Inglewood, New Zealand
Abstract:CASE HISTORY A 15-year-old, brown-and-white cat was presented to a veterinary clinic with an ulcerated, reddened 1-cm diameter lesion on the nasal planum.

CLINICAL FINDINGS AND DIAGNOSIS: Histology of a biopsy sample confirmed the lesion was a squamous cell carcinoma (SCC). PCR amplified DNA sequences from two different papillomaviruses. One sequence was from FdPV 2, which has previously been amplified from feline cutaneous SCC. However, the other sequence has not previously been reported, suggesting a novel feline papillomavirus.

CLINICAL RELEVANCE: There is evidence that papillomaviruses promote the development of SCC on sun-exposed skin in humans. This is the first report in a cat of a papillomavirus other than FdPV2 and the first time that multiple papillomaviruses have been detected within a single neoplasm in this species. Whether the papillomaviruses influenced the development and behaviour of this SCC is currently uncertain, but this case provides additional evidence of the association between papillomaviruses and feline cutaneous SCC. If papillomaviruses are found to influence the development of SCC this may allow novel strategies to prevent these common neoplasms in cats.
Keywords:Cat  squamous cell carcinoma  papillomavirus  carcinogenesis
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号