| 氨基糖苷类药物耐药新机制——16S rRNA甲基化酶的研究进展 |
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| 引用本文： | 陈琳,陈杖榴,刘健华.氨基糖苷类药物耐药新机制——16S rRNA甲基化酶的研究进展[J].中国兽医科技,2006,36(11):935-939. |
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| 作者姓名： | 陈琳 陈杖榴 刘健华 |
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| 作者单位： | 华南农业大学兽医学院广东省兽药研制与安全评价重点实验室,广东广州510642 |
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| 基金项目： | 国家自然科学基金重点项目（30130140）;国家自然科学基金项目（30500373） |
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| 摘 要： | 从16S rRNA甲基化酶的发现、作用机制、基因环境、分布和起源等方面介绍了16S rRNA甲基化酶介导的氨基糖苷类耐药机制。阐明16S rRNA甲基化酶是在革兰氏阴性杆菌中新出现的介导对庆大霉素等氨基糖苷类高度耐药的酶；16S rRNA甲基化酶基因位于质粒和转座子上，具有易于传播和扩散的特点，成为临床抗感染的重要问题。
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| 关 键 词： | 氨基糖苷类 16 S rRNA甲基化酶 耐药机制 质粒 |
| 文章编号： | 1673-4696（2006）11-0935-05 |
| 收稿时间： | 2006-07-13 |
| 修稿时间： | 2006-09-19 |
Novel resistance mechanism of aminoglycosides in Gram-negative bacilli.a review of 16 S rRNA methylase |
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| CHEN Lin,CHEN Zhang-liu,LIU Jian-hua.Novel resistance mechanism of aminoglycosides in Gram-negative bacilli.a review of 16 S rRNA methylase[J].Chinese Journal of Veterinary Science and Technology,2006,36(11):935-939. |
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| Authors: | CHEN Lin CHEN Zhang-liu LIU Jian-hua |
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| Abstract: | Advances in 16 S rRNA methylases, Gram-negative bacilli, were reviewed with regard to which mediate aminoglycosides resistance in clinical their emergence, mechanisms, genetic environments, prevalence and origin. These enzymes are capable of conferring an extraordinarily high level of resistance against most of clinically important aminoglycosides. The genes encoding these enzymes are located in transferable large plasmids and transposons. The spread of such resistance determinants has become a great clinical concern. |
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| Keywords: | aminoglycoside 16 S rRNA methylase resistance mechanism plasmid |
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