Comment on "Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila" |
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Authors: | Sonderegger Peter Patthy Laszlo |
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Institution: | Department of Biochemistry, University of Zurich, CH-8057 Zürich, Switzerland. Peter.Sonderegger@bioc.uzh.ch |
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Abstract: | Didelot et al. (Reports, 11 August 2006, p. 851) claimed that Drosophila Tequila (Teq) and human neurotrypsin are orthologs and concluded that deficient long-term memory after Teq inactivation indicates that neurotrypsin plays its essential role for human cognitive functions through a similar mechanism. Our analyses suggest that Teq and neurotrypsin are not orthologous, leading us to question their equivalent roles in higher brain function. |
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