| 银杏酸和槟榔碱二元微乳剂的研制 |
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| 引用本文： | 刘萌,杨小明,何广立,丁艳. 银杏酸和槟榔碱二元微乳剂的研制[J]. 安徽农业科学, 2010, 38(5): 2446-2448 |
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| 作者姓名： | 刘萌 杨小明 何广立 丁艳 |
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| 作者单位： | 1. 江苏大学化学化工学院,江苏镇江,212013
2. 江苏省镇江市疾病预防控制中心,江苏镇江,212013 |
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| 基金项目： | 江苏省社会发展基金项目(BS2005042);;镇江市社会发展基金项目(SH2008056) |
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| 摘 要： | [目的]制备银杏酸和槟榔碱二元微乳剂。[方法]采用滴定法绘制伪三元相图,考察表面活性剂、助表面活性剂和油相对微乳区的影响。[结果]当DBS-Ca和农乳600#的质量比Km=1∶1时,DBS-Ca-农乳600#-乙酸乙酯-水体系形成的微乳区面积最大,对药物的容量也最大;当表面活性剂和助表面活性剂的总质量与乙酸乙酯的质量比（AS/O）=3∶2时,制得的二元微乳剂最稳定。[结论]该微乳体系制得的银杏酸和槟榔碱二元微乳剂符合要求。
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| 关 键 词： | 银杏酸 槟榔碱 伪三元相图 二元微乳剂 |
Study on Binary Micro-emulsion of Ginkgolic Acids and Arecoline |
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| LIU Meng et al. Study on Binary Micro-emulsion of Ginkgolic Acids and Arecoline[J]. Journal of Anhui Agricultural Sciences, 2010, 38(5): 2446-2448 |
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| Authors: | LIU Meng et al |
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| Affiliation: | School of Chemistry and Chemical Engineering;Jiangsu Uiversity;Zhenjiang;Jiangsu 212013 |
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| Abstract: | [Objective] The aim was to prepare binary micro-emulsion of ginkgolic acids and arecoline.[Method] By using titration method to prepare the pseudoternary phase diagram,the effects of surfactants,co-surfactants,oils on micro-emulsion regions were examined.[Result] The results showed that the area of the micro-emulsion was the largest when the Km value was 1∶ 1 in the system of DBS-Ca/phenylethyl phenol polyoxyethylene ether/ethyl acetate/water,which had the maximum capacity of drugs.When the value of AS/O equaled 3∶ 2,the binary micro-emulsion had the best stability.[Conclusion] The binary micro-emulsion of ginkgolic acids and arecoline obtained by this system suffices the quality standard of micro-emulsion. |
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| Keywords: | Ginkgolic acids Arecoline Pseudoternary phase diagram Binary micro-emulsion |
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