Immature T cell neoplasms in three young cattle |
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| Authors: | Rie YOKOTA Kenshi SATO Yoshihiro WADA Yoshiharu ISHIKAWA Koichi KADOTA |
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| Affiliation: | 1)Toyama Prefectural Tobu Livestock Hygiene Service Center, 46 Mizuhashikanaoshin, Toyama 939–3548, Japan;2)Nemuro Livestock Hygiene Service Center, 69 Betsukaimidorimachi, Betsukai, Hokkaido 086–0214, Japan;3)Ishikari Livestock Hygiene Service Center, 3 Hitsujigaoka, Toyohira, Sapporo 062–0045, Japan;4)Hokkaido Research Station, National Institute of Animal Health, 4 Hitsujigaoka, Toyohira, Sapporo 062–0045, Japan |
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| Abstract: | Immature T cell neoplasms in three young Holstein cattle with neoplastic involvement ofthe thymus are described. Case 1, with a precursor T lymphoblastic leukemia (calf form ofleukosis), was an 86-day-old female calf. The leukemia was characterized by replacement ofthe bone marrow and spleen by leukemia cells, but preservation of epithelial frameworksthroughout the thymus. The other two neoplasms were thymic γδ T cell lymphomas, which wereobserved in a 246-day-old steer (case 2) and a 16-month-old heifer (case 3). Histologicalexamination revealed obliteration of the normal thymic architecture and stromal fibrosis,with the spleen and liver far less severely affected than in case 1. There werecytological differences bewteen the tumors in case 1 and cases 2 and 3. Additionally, WC1and CD8 were expressed only in the latter. Thus, the leukemia and these lymphomas shouldbe regarded as independent disease entities on the basis of histological andimmunohistochemical characteristics. |
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| Keywords: | cattle, juvenile leukosis, lymphoblastic leukemia, thymic γ δ T cell lymphoma |
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