A comparison of commercial modified-live PRRSV-1 and PRRSV-2 vaccines against a dual heterologous PRRSV-1 and PRRSV-2 challenge in late term pregnancy gilts |
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| Affiliation: | 1. College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China;2. Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA;3. Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA;1. College of Veterinary Medicine, Shandong Agricultural University, and Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Taian 271000, China;2. East China Research Center of Animal Epidemic Pathogen Biology, Ministry of Agriculture and Rural Affairs of China, Taian 271000, China;3. Shandong Centers for Animal Disease Control and Prevention, Jinan 250022, China;4. College of Resources and Environment, Shandong Agricultural University, Taian 271000, China;5. Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 251000, China;6. Shandong Key Laboratory of Animal Disease Control and Breeding, Jinan 250100, China;1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China;2. Henan Key Laboratory of Insect Biology in Funiu Mountain, Henan Provincial Engineering Laboratory of Insects Bio-reactor, China-UK-NYNU-RRes Joint Laboratory of Insect Biology, Nanyang Normal University, Nanyang 473061, China;3. School of Modern Agriculture and Biotechnology, AnKang University. Ankang 725000, China |
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| Abstract: | This study compared the efficacy, in terms of reproductive performance, of a porcine reproductive and respiratory syndrome virus (PRRSV)-1 or PRRSV-2 modified-live virus (MLV) vaccine against a dual heterologous PRRSV-1 and PRRSV-2 challenge. Gilts were administered either the PRRSV-1 or PRRSV-2 MLV vaccine at 21 days prior to breeding and were challenged intranasally with both PRRSV species at day 93 of gestation. Vaccination of gilts with PRRSV-2 MLV vaccine resulted in improved reproductive performance in sows (e.g. duration of pregnancy) and piglet health and overall viability (e.g. increase of the number of live-born and weaned pigs, and decrease of stillborn). Vaccination of gilts with PRRSV-1 MLV vaccine was able to reduce only PRRSV-1 viremia in contrast, PRRSV-2 MLV vaccine was able to reduce both PRRSV-1 and PRRSV-2 viremia. Vaccination of gilts with PRRSV-2 MLV induced higher numbers of PRRSV-2 specific interferon-γ secreting cells (IFN-γ-SC) compared to the PRRSV-1 MLV while there was no difference in the number of PRRSV-1 specific IFN-γ-SC between the two vaccines. Taken together, the results presented here suggest that vaccination of gilts with the PRRSV-2 MLV vaccine is more efficacious against dual heterologous PRRSV-1 and PRRSV-2 challenge compared to the PRRSV-1 MLV vaccine. |
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| Keywords: | Porcine reproductive and respiratory syndrome virus Reproductive failure Sow Vaccine |
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