Evaluation of the effect of Toxocara cati infection in the mouse model of allergic asthma: Exacerbation of allergic asthma symptoms and Th2 types of response |
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| Institution: | 1. Departamento de Medicina Veterinária, Universidade Federal Rural de Pernambuco, Recife, PE, Brazil;2. Departamento de Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, PE, Brazil;3. Departamento de Medicina Veterinária Universidade Federal de Campina Grande, Patos, PB, Brazil;4. Superintendência em Saúde, Administração do Distrito Estadual de Fernando de Noronha, Fernando de Noronha, PE, Brazil;1. Laboratory of Microbiology and Immunology, National School of Veterinary Medicine, Institution of Agricultural Research and Higher Education, University of Manouba, 2020 Sidi Thabet, Tunisia;2. National Centre for Zoosanitary Vigilance, 38 Avenue. Charles Nicolle, 1082 Tunis, Tunisia;3. Department of Animal Infectious Diseases, Zoonoses and Sanitary Regulation, National School of Veterinary Medicine, Institution of Agricultural Research and Higher Education, University of Manouba, 2020 Sidi Thabet, Tunisia;1. Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran;2. Department of Food Hygiene and Aquatic, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran;3. Master Student of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran;1. Departamento de Sanidad Animal, Facultad de Veterinaria, UCO, Campus Universitario de Rabanales, 14071 Córdoba, Spain;2. Grupo de Sanidad y Biotecnología, Instituto de Investigación en Recursos Cinegéticos, Universidad de Castilla la Mancha, (SaBio-IREC, UCLM-CSIC-JCCM), 13005, Ciudad Real, Spain;3. Departamento de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, UCO, Campus Universitario de Rabanales, 14071 Córdoba, Spain;4. Unidad de Enfermedades Infecciosas, Grupo de Virología Clínica y Zoonosis, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario de Córdoba, 14004 Córdoba, Spain;5. IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain |
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| Abstract: | Toxocariasis is considered a neglected disease despite the importance of Toxocara spp. infections for human health and is little recognized as a significant problem by public health institutions in developing countries. Epidemiological studies suggest that infection with Toxocara cati contributes to the development of allergic asthma.In the present study, we investigated the effect of T. cati infection on experimental allergic airway inflammation using murine model. BALB/c mice were infected by oral administration with 500 embryonated T. cati eggs followed by ovalbumin (OVA) sensitization and challenge to induce allergic airway inflammation. Infection with T. cati in combination with OVA treatment leads to exacerbation of pulmonary inflammation, eosinophilia, airway hyperresponsiveness, OVA specific IgE. Cytokines measurement in bronchoalveolar lavage indicated that the levels of IL-4 and IL-5 in BAL fluid significantly increased after T. cati infected, OVA treated or a combination of both. Increased level of IL-5 was measured in the lungs of T. cati-infected or OVA-treated mice compared with controls. Moreover, combining infection and OVA treatment significantly increase the level of these cytokines.A direct association between T. cati infection and asthma was found in murine model. Although a wide range of helminth species have been demonstrated to modulate allergic responses, most notably the intestinal nematode T. cati, increases airway hyperresponsiveness, lung histopathology, eosinophil recruitment, and Th2 cytokines in alum-sensitized models of airway allergy. |
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| Keywords: | experimental allergic airway inflammation mice |
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