Laboratory and clinical findings and their association with viral and proviral loads in cats naturally infected with feline leukemia virus |
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| Affiliation: | 1. Department of Veterinary Clinical Pathology, School of Veterinary Medicine at the Federal University of Rio Grande do Sul, Porto Alegre, Brazil;2. Department of Microbiology, Immunology, and Parasitology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;3. Department of Animal Medicine, School of Veterinary Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;4. Veterinary Private Practice, Porto Alegre, Brazil;1. Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran;2. Department of Food Hygiene and Aquatic, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran;3. Master Student of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran;1. Laboratory of Microbiology and Immunology, National School of Veterinary Medicine, Institution of Agricultural Research and Higher Education, University of Manouba, 2020 Sidi Thabet, Tunisia;2. National Centre for Zoosanitary Vigilance, 38 Avenue. Charles Nicolle, 1082 Tunis, Tunisia;3. Department of Animal Infectious Diseases, Zoonoses and Sanitary Regulation, National School of Veterinary Medicine, Institution of Agricultural Research and Higher Education, University of Manouba, 2020 Sidi Thabet, Tunisia;1. Department of Biomedical Sciences, USA;2. Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA;1. Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany;2. Laboratório de Virologia, Departamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil;3. Max von Pettenkofer Institute & Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany;4. InBIO – Research Network in Biodiversity and Evolutionary Biology, CIBIO, Campus de Vairão, Universidade do Porto, Vairão, Portugal;5. Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, Porto, Portugal;6. Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA;1. Laboratório de Imunologia e Doenças Infectocontagiosas. Departamento de Medicina Veterinária. Instituto Federal de Educação, Ciência e Tecnologia da Paraíba, IFPB, Sousa, Paraíba, Brasil;2. Departamento de Morfologia, Universidade Federal da Paraíba, UFPB, João Pessoa, Paraíba, Brasil |
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| Abstract: | This study was conducted to correlate clinical, laboratory, and bone marrow (BM) changes in cats naturally infected with feline leukemia virus and their association with viral loads in blood and BM and proviral loads in BM. Cats were classified into five groups based on antigenemia, clinical and/or laboratory findings and viral/proviral loads, according to a prospective study: symptomatic progressive (GI); asymptomatic progressive (GII); regressive (GIII); unclassified (GIV); or healthy (GV). |Correlations between these five groups and viral/proviral loads were evaluated. High viral and proviral loads were detected in GI and GII and viral loads were significantly associated with laboratory signs. Proviral loads detected in BM were significantly lower in GIII and GIV. GI cats were more likely to develop hematopoietic disorders than those from the other groups. Hematological and clinical disorders and disease severity are related to higher viral blood and proviral BM loads. |
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| Keywords: | Feline retrovirus Laboratory abnormalities Hematopoietic disorders Bone marrow Virus quantification |
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