Pharmacokinetics and bioavailability of oxytetracycline in
vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell |
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Authors: | Kazuaki Uno Tidaporn Chaweepack Lila Ruangpan |
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Institution: | 1. Laboratory of Food Safety, Department of Sciences for Living, Aichi Konan College, Konan, Aichi, 483-8086, Japan 2. Chanthaburi Coastal Fisheries Research and Development Center, Bangkaja, Muang Chanthaburi, 22000, Thailand 3. Department of Fisheries, Ministry of Agriculture and Cooperative, Chatuchak, Bangkok, 10900, Thailand
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Abstract: | The present study examined the pharmacokinetics and bioavailability of oxytetracycline (OTC) in vannamei shrimp (Penaeus vannamei) after intra-sinus (10 mg/kg) and oral (10 and 50 mg/kg) administration and also investigated the net changes of OTC residues in the shrimp after the thermal, acid and alkaline processing methods. The hemolymph concentrations of OTC after intra-sinus dosing were best described by a two-compartment open model. The oral bioavailability was found to be 48.2 and 43.6% at doses of 10 and 50 mg OTC/kg, respectively. The peak hemolymph concentrations after 10 and 50 mg OTC/kg doses were 3.37 and 17.4 μg/ml; the times to peak hemolymph concentrations were 7 and 10 h. The elimination half-lives were found to be 15.0 and 11.5 h for the low and high dose, respectively. The residual OTC was rapidly eliminated from muscle with the elimination half-life value of 19.4 and 15.4 h, respectively, for the groups treated with doses of 10 and 50 mg/kg. The residual OTC levels in the muscle fell below the MRL (0.2 μg/g) at 72 and 96-h post-dosing at dose levels of 10 or 50 mg/kg, respectively. Residual OTC levels in muscle and shell were approximately 20–50% lower in the thermal treatment such as boiling, baking and frying. By the acid treatment, OTC residues were reduced to >80%, while those were reduced to around 30% by alkaline treatment. |
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