Variations in cartilage catabolism in different equine joints in response to interleukin-1 in vitro |
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Authors: | Fuller C J Barr A R Dieppe P A |
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Affiliation: | Department of Clinical Veterinary Science, University of Bristol, Langford. |
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Abstract: | An explant system was used to investigate the hypothesis that cartilage from different equine joints might respond differently to challenge with interleukin-1alpha (IL-1alpha). Pairs of normal cartilage samples were taken from the metacarpophalangeal, proximal interphalangeal and distal interphalangeal joints of six horses. One of each pair was stimulated with 10 ng/ml human recombinant IL-1alpha for three days, and the supernatants and remaining cartilage explants were analysed for their total content of glycosaminoglycans. A significantly higher percentage of glycosaminoglycans was released from the cartilage of the proximal and distal interphalangeal joints than from the metacarpophalangeal joint. |
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