ESI FTICR-MS Analysis of Larvae from the Marine Sponge Luffariella variabilis |
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| Authors: | Cherie A. Motti Piers Ettinger-Epstein Richard H. Willis Dianne M. Tapiolas |
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| Affiliation: | 1. Australian Institute of Marine Science, Townsville, Queensland, 4810, Australia; E-Mails: (R.H.W.); (D.M.T.);2. AIMS@JCU, Sir George Fisher Building, James Cook University, Townsville, 4811, Queensland, Australia; E-Mail: (P.E.-E.);3. School of Marine and Tropical Biology, James Cook University, Townsville, 4811, Queensland, Australia |
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| Abstract: | The viviparous Great Barrier Reef sponge Luffariella variabilis (Poléjaeff 1884) contains a range of secondary metabolites, including manoalide (1) and manoalide monoacetate (3). ESI (+) FTICR-MS accurate mass determination has, for the first time, been used to detected the presence of 3 only in an organic extract of a single L. variabilis larva showing that the parentally produced 3 is sequestered in the larva. As 3 has previously been shown to have antibacterial and quorum sensing inhibition activity, and readily converts to 1, which also exhibits similar activity, it may provide a chemical defence against predation and microbial attack. |
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| Keywords: | Luffariella variabilis manoalide monoacetate larvae ESI FTICR-MS constitutive defence |
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