Yeast life-span extension by calorie restriction is independent of NAD fluctuation |
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| Authors: | Anderson Rozalyn M Latorre-Esteves Magda Neves Ana Rute Lavu Siva Medvedik Oliver Taylor Christopher Howitz Konrad T Santos Helena Sinclair David A |
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| Affiliation: | Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston MA 02115, USA. |
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| Abstract: | Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR. |
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