Comparison of the effect of caerulein and testmeal on exocrine pancreatic secretion in the dog

Small doses of caerulein (10, 20, 40, 100 ng/kg/h) were given to conscious dogs with chronic duodenal and gastric fistulas, and the exocrine pancreatic response was compared with that obtained by a testmeal. Maximal protein and bicarbonate secretion varied between 20 and more than 100 ng/kg/h, depending on the individual animal. Testmeal-stimulated pancreatic secretion was approximately equivalent to that achieved with 10 ng caerulein/kg/h. Plasma secretin levels did not change significantly during testmeal stimulation.