Effects of Subchronic Aluminum Exposure on Amino Acids Neurotransmitters in Chicken Brain |
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Authors: | Han Yan-fei Xia Shi-liang Bai Chong-sheng Zhang Ji-hong Li Yan-fei |
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Institution: | College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China |
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Abstract: | To investigate the effects of aluminium (Al) exposure on amino acid neurotransmitters, the chickens with different levels of subchronic Al poisoning were estabolished by continuous peritoneal injection of fixed volume and different concentrations of gradient of aluminium trichloride (AlCl3). The levels of amino acid neurotransmitters in chicken brains were determined by high performance liquid chromatography (HPLC) after being exposed of Al for 60 days, and Al levels in serum and brain tissue were determined by atomic absorption spectrophotometry (AAS). The results showed that Glu levels increased with the increase of Al, but there was no significant difference compared with the control. The levels of Al, Asp, Gly, GABA and Tau were significantly higher in Al-treated groups than those in the control. The results indicated that Al intoxication led to excitatory neurotoxicity. |
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Keywords: | subchronic aluminum exposure chicken brain amino acid neurotransmitters |
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