In vitro antimicrobial activity of hydroxy and N4‐acetyl sulphonamide metabolites |
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| Authors: | J F M Nouws T B Vree Y A Hekster |
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| Institution: | 1. Meat Inspection Service , Wolfskuilseweg 279, Nijmegen, the Netherlands;2. Department of Clinical Pharmacy, Sint Radboud Hospital , University of Nijmegen , Geert Groote Plein Zuid 8, Nijmegen, the Netherlands |
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| Abstract: | Summary Hydroxylated metabolites of sulphadimidine, sulphamerazine, sulphatroxazole, sulphamethoxazole, and sulphadiazine exhibited antimicrobial activity against Escheria coli 28 PR 271 test strain ranging from 2.5 to 39.5 per cent of that of the parent drug. Trimethoprim addition potentiated the antimicrobial activity of these metabolites. N4‐acetyl sulphonamide metabolites possessed no antimicrobial activity, nor did trimethoprim potentiated them. |
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