Biological activity of obiopeptide-1, a synthetic peptide derived from the native immune-regulator obioactin |
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| Authors: | N Suzuki H Sakurai A Saito I Igarashi Y Omata H Osaki |
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| Affiliation: | Department of Veterinary Physiology and Protozoan Immunology, Obihiro University, Hokkaido, Japan. |
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| Abstract: | Tachyzoites of Toxoplasma gondii were killed in mouse macrophage and human somatic cell monolayers by a novel synthetic peptide (Obiopeptide-1) which is a Glycil-penta-Glutaminate (GpG) derivative of native Obioactin. In view of the worldwide prevalence of this protozoan disease and the lack of effective treatments, Obiopeptide-1 may be a new and unique antimicrobial active substance of non-antibiotic chemotherapeutic agents for intracellular parasites, T. gondii and associated nonspecific hypoimmune responses that occur in infected hosts. |
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