| 桔皮素衍生物对离体兔耳痒螨药效筛选试验 |
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| 引用本文： | 王祥生 张祚新. 桔皮素衍生物对离体兔耳痒螨药效筛选试验[J]. 中国兽医寄生虫病, 1999, 7(3): 16-17 |
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| 作者姓名： | 王祥生 张祚新 |
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| 作者单位： | 解放军农牧大学军事兽医研究所 |
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| 摘 要： | 将桔皮素化学结构改造后获得的７种衍生物制成乳浊液含桔皮素１２．５％，再按要求稀释至所需浓度，对离体兔耳痒螨进行药效筛选试验。结果新衍生物有较好的杀螨作用，效果优于灭螨灵，与双甲脒、螨净相近。试验表明，０．０２％的磺酸取代物在４０ｍｉｎ内将螨虫全部杀灭，０．０５％桔皮素的溴取代物－１、溴取代物－２、碳酸酯、甲基酮－１和甲基酮－２分别在３５、３０、２０、１６和４０ｍｉｎ内将螨虫全部杀灭，０．０５％和０．０２％的桔皮素乙酰酯分别在５和１０ｍｉｎ内将螨虫全部杀灭。对照药品灭螨灵、螨净在０．０２％浓度时分别在１５和１４ｍｉｎ内将螨虫全部杀灭。
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| 关 键 词： | 桔皮素衍生物；药效筛选；耳痒螨 |
PHARMACODYNAMICALSCREENINGTESTINVITROOFDERIVATIVE TANGERINEPEELACTIVEPRINCIPLEONRABBITEARPSOROPTES |
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| WANGXiangsheng,ZHANGZuoxin,CAIHui,YANGYongsheng,WUYongkui,LIUXiaofang. PHARMACODYNAMICALSCREENINGTESTINVITROOFDERIVATIVE TANGERINEPEELACTIVEPRINCIPLEONRABBITEARPSOROPTES[J]. Chinese Journal of Veterinary Parasitology, 1999, 7(3): 16-17 |
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| Authors: | WANGXiangsheng ZHANGZuoxin CAIHui YANGYongsheng WUYongkui LIUXiaofang |
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| Abstract: | Sevenderivatesoftangerinepeelactiveprincipleweremadeintoemulsion,anddilutedtothenecessaryconsistency.Thusstartthepharmacodynamicalscreeningtestinvitroonrabbitearpsoroptes.Theresultshowedthatthederivatesoftangerinepeelactiveprinciplepossessagreatofkillingrabbitearpsoroptesaction.Itseffectissuperiortothatoftangerinepeelactiveprinciple,andissimilartothatofAmitrazeandDimplate.0.02%sulfonicacidderivatekilledallrabbitearpsoroptesin40min;In0.05%consistencybromoderivate1killedallrabbitearpsoroptesin35min,bromoderivate2in30min,corbonatederivatein20min,methylketonederivate1in16min,methylketonederivate2in40min,respectively;0.05%and0.02?etatederivatekilledalltherabbitearpsoroptesin5minand10min,respectively;0.02%tangerinepeelactiveprincipleandDimplatekilledalltherabbitearpsoroptesin15minand14min,respectively. |
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| Keywords: | derivateoftangerinepeelactiveprinciple pharmacodynamicalscreen rabbitearpsoroptes |
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