四川红桔皮化学成分对家兔耳(足)螨病治疗试验

用从四川红桔皮中提取的7种化学成分,即川陈皮素(nobiletin)、蜜桔素(tangeratin),5-去甲川陈皮素(5-o-demethyl nobiletin)、4',5,7,8-四甲氧基黄酮(4',5,7,8-tetrahydroxylflavone)、麝香草酚(thymol)、β-谷甾醇(β-sitosterol)、异橙黄酮(isosi-nensetin) (依次用A,B,C,D,E,F,G代表),对兔螨进行了离体杀灭比较试验。结果以C、D、G杀螨力较强,其中又以G最强,1000倍稀释G液15 min能杀死10/10螨虫,C、D液则需4 h才能杀死10/10螨虫,对照组14 h仍有7/10螨虫存活。用G和桔皮油、辛硫磷对比杀螨,G 5～20 min、枯皮油5～30 min均可杀死10/10螨虫,而辛硫磷在6 h还有3/10活螨.以不同稀释倍数G液对5只耳螨兔进行治疗试验,结果250-500倍稀释G液治疗3 d 5/5治愈,1 000-10 000倍稀释者需7～14 d才全部治愈.进而用250-500倍稀释G液对不同养兔单位的208只耳(足)螨兔扩大治疗试验,有效率为100％,其中连续用药2～3次者,97.3％完全治愈,2.7％好转;仅治疗1次者,92％完全治愈,8％好转.用G液治疗兔螨病,无任何毒副作用.

Treatment for Ear ( Foot ) Scabies of Rabbit with Same Components of Citrus Reticulata Blano

The mitecidal effect of orange peel oil land the chemical constituents of the orange peel have been reported previously. In this experiment, 7 components ate selected for evaluating their mitecidal potency in vitro individually. It was shown that 5 -0-demethyl nobiletin occupies first place, phoxin comes second. And then, two hundred and eight cases of rabbit acabies are treated with 5 - 0 -demethyl nobiletin diluted 250-500 times. Its effective rate was 100%. If administer for 2 - 3 times,97.3% of infested rabbits could be cured; even though only once, the curative rate may be up to 92%. No toxic and side effects are found.