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Dyspnea Caused by an Obstructive Tracheal Leiomyoma in a Horse: A Rare Case
Affiliation:1. Cuerpo Académico de Zoonosis y Enfermedades Emergentes, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, Escobedo, Nuevo León, México;2. Epidemiología Veterinaria, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, Escobedo, Nuevo León, México;3. Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada;1. Department of Animal Science, Universidade do Estado de Santa Catarina (UDESC), Chapecó, Santa Catarina, Brazil;2. Department of Veterinary Medicine, Universidade do Estado de Santa Catarina (UDESC), Lages, Santa Catarina, Brazil;3. Department of Physiology and Pharmacology, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil;4. Department of Aesthetics and Cosmetics, Universidade Luterana do Brasil, Santa Maria, Rio Grande do Sul, Brazil;1. Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Faculty of Veterinary Medicine, Karaj branch of Islamic Azad University, Karaj, Iran;4. Telemedicine Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Department of Clinical Science, Surgery and Radiology Section, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;1. Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China;4. Department of Anesthesia, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China;2. Guangzhou Research Institute of Respiratory Disease, China Key Laboratory of Respiratory Disease, Guangdong, China;3. National Center for Clinical Trials on Respiratory Diseases, Guangdong, China;1. Centro de Investigación en Encefalopatías y Enfermedades Transmisibles Emergentes, Departamento de Patología Animal, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain;2. Unidad de Microbiología e Inmunología, Departamento de Patología Animal, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain;3. Departamento de Anatomía, Embriología y Genética Animal, Laboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain;4. Departamento de Patología Animal, Hospital Veterinario, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain;1. Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Bologna, Italy;2. AUB-INFA, University of Bologna, Granarolo dell’Emilia, Bologna, Italy;3. Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Texas A&M University, College Station, TX
Abstract:Tracheal leiomyoma is a rare neoplasm of the respiratory tract in animals. This primary benign tumor arises from smooth muscle cells of the trachea. We report a 13-year-old female horse with clinical signs of severe airways obstruction. It had dyspnea, exercise intolerance, chronic progressive respiratory noises, and cyanosis in mucosa membranes. Radiography revealed a foreign body obliterating the luminal trachea. Endoscopic biopsy showed a 3 × 3-cm ovoid mass attached to the dorsal aspect of the trachea. Hematoxylin and eosin and Masson's trichrome stains showed dense spindle cells forming irregular bundles disposed in short interlacing fascicles. Nuclei were elongated with blunt ends, eosinophilic cytoplasm with indistinguishable cell borders, and low mitotic activity. This study is considered the first reported case of an obstructive intratracheal leiomyoma in the horse.
Keywords:Airway obstruction  Histopathology  Horse  Leiomyoma  Smooth cell muscle tumor  Trachea
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