Cloning of cDNAs encoding multiple subtypes of feline interferon-alpha from the feline epitherial cell line |
| |
| Authors: | Nagai Ayuko Taira Osamu Ishikawa Miyuki Hiramatsu Kentaro Hohdatsu Tsutomu Koyama Hiroyuki Arai Setsuo Sato Hisaaki Nakano Katsushige Maehara Nobutoshi |
| |
| Affiliation: | Department of Veterinary Microbiology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Japan. |
| |
| Abstract: | Mammalian interferon (IFN)-alpha consists of a 23-amino acid signal peptide and a 166-amino acid mature protein. Feline (Fe) IFN-alpha has an extra unique molecule consisting of a 171-amino acid mature protein with a 5-amino acid insertion. We cloned eight new subtypes of cDNA encoding FeIFN- alpha from a feline epithelial cell line. Among all the FeIFN-alpha subtypes, including six that have previously been reported, the variations were found to be far less than those of IFN-alphas of other animals. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
