细菌重组减毒鼠伤寒沙门氏菌疫苗研究进展

鼠伤寒沙门氏菌 ( St)是一种肠道致病菌 ,通过基因突变可构建许多鼠伤寒沙门氏菌减毒株 ,例如 :X40 72、X42 17、X45 5 0、X4989、X4990、 X40 64、 SL 3 2 61、 GID10 1、 GID10 5、GID10 6和 BRD5 0 9等 ,它们均是两个或多个基因的精确突变 ,其基因型和表型均很稳定 ,可用作构建细菌性疫苗的表达载体。国内外学者相继研制了肺炎链球菌、结核杆菌、百日咳杆菌、产单核细胞李斯特菌、鼠疫耶尔森菌、土拉弗郎西斯菌、铜绿假单胞菌、淋病奈瑟菌、牛布氏杆菌、破伤风梭菌、炭疽芽孢杆菌、沙眼衣原体和猪肺炎支原体等细菌的重组减毒鼠伤寒沙门氏菌疫苗。文章着重讨论了这些疫苗的构建及其免疫机制等方面的研究进展 ,从而为新型菌苗的研制提供一种新的思路

The Research Progress of Recombinant Attenuated Salmonella typhimurium Vaccine of Bacteria

Salmonella typhimurium is one type of enteric pathogenic bacteria.Many attenuated strains such as X4072,X4217,X4550,X4989,X4990,X4064,SL3261,GID101,GID105,GID106 and BRD509 were constructed by gene mutation;which are precise mutation of two or many gene.Their genotype and phenotype are very stable,so they are acted as expression vector to make bacterial vaccine.Many recombinant attenuated Salmonella typhimurium vaccine of bacteria have been studied in succession,those bacteria include Streptococcus pneumoniae , Mycobacteria tuberculosis , Bordetella pertussis , Listeria monocytogenes , Yersinia pestis , Francisella tularensis , Pseudomonas aeruginosa , Neisseria gonorrhoeae , Brucella abortus , Clostridium tetanus, Bacillus anthracis , Chlamydia trachomatis and Mycoplasma hyopneumoniae .The construction and its immune mechanism of those vaccine were emphasized to discuss in this review.