MS-222在草鱼、花鲈、鲫鱼组织中的富集与消除

在水温(22±2)℃条件下,将平均体质量约为100 g的健康草鱼、花鲈、鲫鱼在50 mg/L的间氨基苯甲酸乙酯甲磺酸盐(MS-222)药液中浸泡,分别于药浴0.5、1、2、3、7 h和10 h时取样测定肌肉、肝(胰)脏、血液中MS-222的残留量,10 h后将试验鱼置于清洁水中,分别于0.5、1、2、4、6、8、16、32、96、120、192、264、336、432、528、624、720 h时再测定肌肉、肝(胰)脏、血液中MS-222的残留量。结果显示,MS-222在草鱼、花鲈、鲫鱼的血液、肌肉、肝(胰)脏中残留分别在3、3、7 h达到峰值,随后略下降;MS-222在草鱼血液、肌肉、肝胰脏组织中的消除半衰期分别为5.4、6.7、7.9 h;在花鲈血液、肌肉、肝脏组织中的消除半衰期分别为3.9、5.1、5.7 h;在鲫鱼血液、肌肉、肝胰脏组织中的消除半衰期分别为 4.8 、6.3、8.4 h。MS-222在3种鱼类肝(胰)脏、肌肉、血液中的消除速率均为 V肝(胰)脏

Accumulation and Elimination Dynamics of Anesthetic MS-222 in Tissues of Grass Carp,Bass and Crucian Carp

Healthy grass carp Ctenopharyngodon idellus ,bass Lateolabrax maculatus and crucian carp Carassius auratus with body weight of about 100 g were bathed in 50 mg/L tricaine methanesulfonate (MS-222) solution at water temperature of (22±2)℃ for 10 h,and the MS-222 residues in muscles,liver and blood were measured 0.5,1,2,3,7,and 10 h after the medicine bath,and 0.5,1,2,4,6,8,16,32,96,120,192,264,336,336,264,336,432,528,624,and 720 h after recovery in clean water. The results showed that the peak MS-222 residues in the blood,muscle and liver were observed 3,3,and 7 h after the administration of the fish,and then decreased slightly. The elimination half-lives in the plasma,muscle and liver tissues were found to be 5.4,6.7 and 7.9 h in grass carp, 3.9 ,5.1 and 5.7 h in bass,and 4.8,6.3 and 8.4 h in crucian carp. The order of elimination rate of MS-222 in three tissues was expressed as liver