The kinetic disposition and dosage regimen for carbenicillin in buffalo calves |
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Authors: | M. S. Bal K. S. Brar |
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Affiliation: | (1) Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, 141004 Ludhiana, India |
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Abstract: | The distribution half-life, elimination half-life, apparent volume of distribution and total body clearance of carbenicillin in healthy buffalo calves following a single intravenous administration (50 mg/kg) were 0.057±0.005 h, 1.688±0.11 h, 0.185±0.021 L kg-1 and 75.97±6.519 ml kg-1 h-1 respectively. A satisfactory dosage regimen for carbenicillin in buffalo calves was calculated to be 56 mg/kg followed by 52 mg/kg body weight repeated at 6 h intervals. |
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Keywords: | buffalo carbenicillin pharmacokinetics therapeutics |
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