A Random Effects Model for Binary Mixture Toxicity Experiments |
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Authors: | Helle Sørensen Nina Cedergreen Jens C Streibig |
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Institution: | (1) College of Chemistry and Bioengineering, Guilin University of Technology, 541004 Guilin, China;(2) Baise Vocational College, 533000 Baise, China;(3) State Key Laboratory of Pollution Control and Resources Reuse, Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, 200092 Shanghai, China; |
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Abstract: | We suggest a simple isobole analysis for binary mixture toxicity experiments. The analysis is based on estimated logarithmic
effect concentrations and their corresponding standard errors. The suggested model allows for synergism/antagonism and incorporates
within-mixture variation as well as between-mixture variation in a random effects model. The likelihood ratio test for the
hypothesis of concentration addition (CA) is examined, in particular its small sample properties. We study two datasets on
the joint effect of acifluorfen versus diquat and glyphosate versus mechlorprop, respectively, on the growth of the aquatic
macrophyte Lemna minor. |
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Keywords: | |
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