| 山羊乳上皮黏蛋白MUC1的遗传多态性及其在进化分析中的应用 |
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| 引用本文： | 郑玉才,王杰,白文林.山羊乳上皮黏蛋白MUC1的遗传多态性及其在进化分析中的应用[J].畜牧兽医学报,2006,37(10):967-971. |
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| 作者姓名： | 郑玉才 王杰 白文林 |
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| 作者单位： | 西南民族大学生命科学与技术学院,成都,610041 |
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| 基金项目： | 四川省应用基础项目（01NY051-05）;西南民族大学科研项目（234072） |
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| 摘 要： | 研究了四川5个地方山羊品种及波尔山羊乳上皮黏蛋白MUC1的遗传多态性。结果显示，山羊乳MUC1表现出丰富的多态性，共检测到22种基因型和9个等位基因，编码的蛋白质分子量范围为205～278ku，明显高于普通乳牛；MUC1的等位基因、基因型及其分布存在品种间差异；山羊乳MUC1基因杂合度较大，遗传变异程度高；根据乳MUC1等位基因频率对6个山羊品种进行了聚类分析，结果能较好地反映各品种间的亲缘关系。
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| 关 键 词： | 山羊 乳 MUC1 遗传多态性 聚类分析 |
| 文章编号： | 0366-6964（2006）10-0967-05 |
| 收稿时间： | 2005-08-17 |
| 修稿时间： | 2005-08-17 |
Genetic Polymorphism and Application in Evolution Analysis of the Epithelial MUC1 in Milk Samples from Goat |
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| ZHENG Yu-cai,WANG Jie,BAI Wen-lin.Genetic Polymorphism and Application in Evolution Analysis of the Epithelial MUC1 in Milk Samples from Goat[J].Acta Veterinaria et Zootechnica Sinica,2006,37(10):967-971. |
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| Authors: | ZHENG Yu-cai WANG Jie BAI Wen-lin |
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| Institution: | College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, China |
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| Abstract: | Genetic polymorphisms of milk epithelial mucin, MUC1, were assayed in five local goat breeds of Sichuan Province and Boer goat. Goat milk MUC1 exhibited rich genetic polymorphisms. A total of 22 genotypes and eight alleles of MUC1 were revealed in the goat breeds tested. Molecular weight of goat milk MUC1 was in the range of 205 ku to 278 ku, which were obviously higher than that of bovine. Alleles, genotypes and genotype distribution of MUC1 differed among the goat breeds. The gene heterozygosity and genetic variation of milk MUC1 was high in goats. Cluster analysis based on milk MUC1 polymorphism of the six goat breeds reflected their actual relationships. |
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| Keywords: | goat milk MUC1 genetic polymorphism cluster analysis |
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