Histopathological Changes in the Pancreas from a Spontaneous Hyperglycemic
Cynomolgus Monkey |
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Authors: | Hideki Fujisawa Zean Zhang Wei Sun Mingshu Huang Junichi Kobayashi Hitoshi Yasuda Yuichi Kinoshita Ryo Ando Kazutoshi Tamura |
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Institution: | 1.Bozo Research Center Inc., 1284 Kamado, Gotemba-shi, Shizuoka 412-0039, Japan;2.Center for Drug Safety Evaluation and Research, Shanghai University of T.C.M., 1200 Cailun Road, Shanghai 201203, China;3.National Shanghai Center for New Drug Safety Evaluation and Research, 199 Guoshoujing Road, Shanghai 201203, China |
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Abstract: | Morphological and immunohistochemical examinations were carried out on the pancreas of a
hyperglycemic 5-year-old male cynomolgus monkey. Body weight gradually decreased from 6
months before termination, accompanying a slight reduction in food consumption and
anorexia for the last 2 days. The blood glucose level was markedly elevated when examined
at termination. Histopathologically, in the exocrine pancreas, diffuse hyperplasia of
centroacinar and intercalated duct cells and diffuse atrophy of acinar cells with sporadic
apoptosis were observed, although most centroacinar and intercalated duct cells were
proliferating cell nuclear antigen (PCNA)-positive in both the present case and
age-matched control animals. In the endocrine pancreas, the islets tended to be
hypertrophic, with an increase in insulin-positive cells in comparison with the
age-matched control animals. PCNA-positive cells also tended to increase in the islets,
although positive cells for phospho-histone H3, a marker for mitotic cells, were not
detected in the endocrine and exocrine pancreas. Moreover, neither inflammation nor
amyloidosis was noted in the islets. In conclusion, the present case probably suffered
from early-stage type 2 diabetes mellitus, and it provides fundamental information
concerning pancreatic histopathology under insulin-related derangement in monkeys. |
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Keywords: | pontaneous diabetes mellitus pancreas β -cell hyperplasia centroacinar and intercalated duct cell hyperplasia cynomolgus monkey |
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