Effects of dioctyl sodium sulfosuccinate on hematological values in normal horses |
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| Authors: | LL Southwood HC Schott II D Wunn SA Hopper WM Bayly |
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| Institution: | 1. Therapeutic Chemistry Department, National Research Centre, Egypt;2. Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt;3. Biochemistry and Nutrition Department, Faculty of Women for Arts, Science and Education, Ain-Shams University, Egypt;4. Department of Medicinal and Aromatic Plants, National Research Centre, Cairo, Egypt;1. Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis 95616;2. Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616;3. California Animal Health and Food Safety Laboratory, University of California, Davis 95616;4. Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Tulare 95616;1. Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, PO Box 1177, Urmia, Iran;2. Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, PO Box 1177, Urmia, Iran;3. Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, PO Box 1177, Urmia, Iran;1. Department of Animal Science, Universidade do Estado de Santa Catarina, Chapecó, SC, Brazil;2. Laboratory of Animal Endocrinology and Metabolism, Program of Post-Graduation in Veterinary Medicine, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil;3. Department of Small Animal, UFSM, Santa Maria, RS, Brazil;4. Department of Microbiology and Parasitology, UFSM, Santa Maria, RS, Brazil;5. Department of Clinical and Toxicological Analysis, UFSM, Santa Maria, RS, Brazil;6. Laboratory of Veterinary Pathology, Instituto Federal Catarinense, Santa Maria, RS, Brazil;1. National R&D Center for Freshwater Fish Processing, and Engineering Research Center of Freshwater Fish High-value Utilization of Jiangxi Province, Jiangxi Normal University, Nanchang, Jiangxi 330022, China;2. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, China |
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| Abstract: | In several horses referred for evaluation of colic, we observed marked leukopenia (attributable to neutrophil counts <2,000/μl) which was inconsistent with the mild nature of abdominal pain, absence of fever, or lack of signs of endotoxemia. In all cases, large bowel impaction has been diagnosed via rectal palpation prior to admission and dioctyl sodium sulfosuccinate (DSS) had been one of the medications administered. To investigate the hypothesis that DSS administration may lead to bowel irritation, margination of neutrophils, and development of leukopenia (neutropenia), the effects of DSS administration (20 mg/kg via a nasogastric tube) on clinical and hematologic values were studied in eight clinically normal horses. No changes were detected in any of the clinical values assessed in these horses and neither leukopenia nor neutropenia was observed following DSS administration. A trend for plasma total protein concentration to increase four hours after DSS administration (in comparison to control data) suggested that DSS may enhance secretion of fluid into the bowel in treated horses. In conclusion, the results did not support the hypothesis that the leukopenia observed in horses with colic could be attributed to DSS administration. Whether DSS has more significant effects in horses with altered bowel motility and mucosal integrity during colic episodes is not known. |
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