Longitudinal evaluation of diagnostics in experimentally infected young calves during subclinical and clinical paratuberculosis |
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| Authors: | Rienske AR Mortier Herman W Barkema Karin Orsel Gregory P Muench Janet M Bystrom Oscar Illanes Jeroen De Buck |
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| Institution: | Department of Production Animal Health (Mortier, Barkema, Orsel, De Buck), Veterinary Science Research Station (Muench), Department of Ecosystem and Public Health (Bystrom), Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta; Department of Biomedical Sciences, School of Veterinary Medicine, Ross University, Basseterre, Saint Kitts, West Indies (Illanes). |
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| Abstract: | Five calves were inoculated orally at 2 weeks of age with a dose of 5 × 109 colony-forming units of Mycobacterium avium subspecies paratuberculosis (MAP) on 2 consecutive days. Two calves developed clinical Johne’s disease at 12 and 16 months of age after being consistently positive for MAP on fecal culture and antibody enzyme-linked immunosorbent assay (ELISA), starting 2 to 3 weeks and 4 to 5 months after inoculation, respectively. |
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