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不同基因辅助选择方法对QTL的选择效率
引用本文:王孝义,李明丽,苟潇,严达伟,鲁绍雄.不同基因辅助选择方法对QTL的选择效率[J].云南农业大学学报,2012,27(5):682-687.
作者姓名:王孝义  李明丽  苟潇  严达伟  鲁绍雄
作者单位:云南农业大学 动物科学技术学院,云南 昆明 650201
摘    要: 在假定目标性状由一个QTL和多基因共同控制的基础上,采用计算机模拟方法研究了在一个闭锁群体内分别采用基因型选择(GTS)、基因辅助BLUP(GBLUP)和常规动物模型BLUP方法对单个性状实施连续选择的效果,并以常规动物模型BLUP为参照,分析了GTS和GBLUP方法对目标性状QTL的选择效率。结果表明:与常规动物模型BLUP相比,GTS和GBLUP选择均可获得更大的QTL基因型值进展,QTL增效等位基因频率上升的速度也更快;与GBLUP相比,GTS方法对QTL的选择效率更高。GTS和GBLUP对QTL的选择优势在短期选择时较为明显,随着世代的递增,这种优势将逐渐降低甚至消失。

关 键 词:动物模型BLUP  基因型选择  基因辅助BLUP  遗传进展  QTL增效等位基因

Efficiencies of QTL Selection under Different Gene assisted Selection Methods
WANG Xiao yi,LI Ming li,GOU Xiao,YAN Da wei,LU Shao xiong.Efficiencies of QTL Selection under Different Gene assisted Selection Methods[J].Journal of Yunnan Agricultural University,2012,27(5):682-687.
Authors:WANG Xiao yi  LI Ming li  GOU Xiao  YAN Da wei  LU Shao xiong
Institution:College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China
Abstract:Assumed that the target trait was controlled by one QTL and polygenes, the effects of continuous selection on single trait in a closed population under genotype selection (GTS), gene assisted best linear unbiased prediction (GBLUP) and conventional animal model best linear unbiased prediction (BLUP) were estatimated by using computer simulation method,respectively. The efficiencies of QTL selection from GTS and GBLUP were analyzed by taking the method of conventional animal BLUP as the control. Compared with those from conventional animal BLUP, GTS and GBLUP would gain higher genetic response of QTL genotypic value, and faster increase of the frequency of QTL favorable allele, and the QTL selective efficiency of GTS was higher than that of GBLUP. The superiority of GTS and GBLUP compared with conventional animal BLUP for QTL selection was much obvious in short term selection, but it would be decreased gradually and even disappeared with the increase of generation
Keywords:animal model BLUP  genotype selection  gene assisted BLUP  genetic response  QTL favorable allele
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