骨碎补总黄酮对骨代谢的影响及作用机制

骨组织维持平衡的关键在于骨代谢的动态平衡。一旦骨代谢失衡,就会导致骨损伤甚至骨骼疾病。中药骨碎补含有主要活性成分——骨碎补总黄酮,该活性物质对骨质疏松、骨缺损、骨折和骨关节炎等骨骼疾病有治疗作用。对国内外相关文献进行归纳总结,从骨组织、血管、骨细胞以及调控机制四个方面综述骨碎补总黄酮对骨代谢的影响,为后续研究提供理论基础。

Effects of Total Flavonoids from Rhizoma Drynariae on Bone Metabolism and Action Mechanisms

The key to maintain the balance of bone tissue is the dynamic balance of bone metabolism. The imbalance of bone metabolism results in bone damages and even bone diseases. Total flavonoids extracted from Rhizoma Drynariae, a traditional Chinese medicine, are active ingredients that have therapeutic effects on bone diseases such as osteoporosis, bone defect, bone fracture and osteoarthritis. Based on the summary of relevant literatures in China and abroad, this paper reviews the effects of total flavonoids from Rhizoma Drynariae on bone metabolism from the aspects of bone tissue, blood vessels, bone cells and related regulatory mechanisms, in hoping to provide theoretical basis for further researches.