| 地塞米松对特发性血小板减少性紫癜外周血淋巴细胞凋亡及Fas/FasL的影响 |
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| 引用本文： | 孟琼,肖红,刘仿,蔡康荣. 地塞米松对特发性血小板减少性紫癜外周血淋巴细胞凋亡及Fas/FasL的影响[J]. 湛江医学院学报, 2004, 22(4): 339-340 |
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| 作者姓名： | 孟琼 肖红 刘仿 蔡康荣 |
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| 作者单位： | 广东医学院附属医院儿科 广东湛江524001(孟琼，肖红)，广东医学院免疫学教研室 广东湛江524023(刘仿)，广东医学院分析中心 广东湛江524023(蔡康荣) |
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| 摘 要： | 目的 :观察地塞米松对特发性血小板减少性紫癜 (ITP)外周血淋巴细胞凋亡及 Fas、Fas L表达的影响及其临床意义。方法 :用流式细胞仪检测 30例 ITP患儿治疗前后外周血淋巴细胞凋亡率及 Fas、Fas L蛋白表达。结果 :治疗前淋巴细胞凋亡率及 Fas、Fas L蛋白表达与对照组相比差异无统计学意义 (P>0 .0 5)。治疗后血小板增加时淋巴细胞凋亡率增加 ,Fas、Fas L蛋白表达上调 ,与治疗前相比差异有显著性意义 (P<0 .0 1 )。结论 :地塞米松可显著促进 ITP患儿外周血淋巴细胞的凋亡 ,上调淋巴细胞 Fas、Fas L的表达 ,有助于清除激活的淋巴细胞。
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| 关 键 词： | 地塞米松 紫癜 血小板减少性 特发性 凋亡 Fas |
| 文章编号： | 1005-4057(2004)04-0339-02 |
| 修稿时间： | 2003-09-03 |
Effect of dexamethasone on apoptosis and Fas/FasL expression from peripheral blood lymphocyte in patients with idiopathic thrombocytopenic purpura |
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| MENG Qiong,XIAO Hong,LIU Fang,CAI Kang-rong. Effect of dexamethasone on apoptosis and Fas/FasL expression from peripheral blood lymphocyte in patients with idiopathic thrombocytopenic purpura[J]. Journal of Guangdong Medical College, 2004, 22(4): 339-340 |
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| Authors: | MENG Qiong XIAO Hong LIU Fang CAI Kang-rong |
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| Abstract: | Objective: To study the effect of dexamethasone on apoptosis and Fas/FasL expression from peripheral blood lymphocyte (PBL) in patients with idiopathic thrombocytopenic purpura (ITP). Methods: PBL apoptosis and Fas/FasL expression in 30 children with ITP pre- and post-treatment of dexamethasone and 22 healthy controls were deter mined by flow cytometry. Results: There were no statistical differences in PBL apoptosis and Fas/FasL expression between the untreated patients and normal controls (P>0.05), but they were significantly up-regulated post-treatment (P<0.01). Conclusion: Dexamethasone could induce PBL apoptosis and Fas/FasL overexpression in patients with ITP, which is helpful in eli minating the activated lymphocytes. |
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| Keywords: | dexamethasone idiopathic thrombocytopenic purpura apoptosis Fas |
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