| 在猪肺泡巨噬细胞上Notch信号通路调控LPS诱导的炎性反应研究 |
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| 引用本文： | 陆艳,杨义,张彦兵,魏建超,刘珂,邵东华,李蓓蓓,马志永,邱亚峰. 在猪肺泡巨噬细胞上Notch信号通路调控LPS诱导的炎性反应研究[J]. 中国动物传染病学报, 2021, 0(2): 53-57 |
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| 作者姓名： | 陆艳 杨义 张彦兵 魏建超 刘珂 邵东华 李蓓蓓 马志永 邱亚峰 |
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| 作者单位： | 中国农业科学院上海兽医研究所 |
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| 基金项目： | 国家重点研发计划课题(2018YFD0500101);中国农业科学院青年英才项目(CAASQNYC-KYYJ-26);中央级公益性科研院所基本科研业务费(2014JB15,2015ZL065)。 |
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| 摘 要： | Notch信号通路可以与TLR信号通路相互作用,协作调控炎性因子的产生以及巨噬细胞的激活.然而,在猪巨噬细胞上,Notcb信号通路是如何调控炎性反应的还不清楚.本研究以LPS/TLR4诱导炎性反应为模型,利用猪肺泡巨噬细胞来研究LPS处理对Notch信号通路的影响及Notch信号通路对LPS诱导炎性反应的调控作用.结果...
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| 关 键 词： | Notch信号通路 LPS 猪肺泡巨噬细胞 炎性因子 |
Notch Signaling Regulates LPS-induced Inflammatory Responses in Porcine Alveolar Macrophages |
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| LU Yan,YANG Yi,ZHANG Yanbing,WEI Jianchao,LIU Ke,SHAO Donghua,LI Beibei,MA Zhiyong,QIU Yafeng. Notch Signaling Regulates LPS-induced Inflammatory Responses in Porcine Alveolar Macrophages[J]. Chinese Journal of Animal Infectious Diseases, 2021, 0(2): 53-57 |
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| Authors: | LU Yan YANG Yi ZHANG Yanbing WEI Jianchao LIU Ke SHAO Donghua LI Beibei MA Zhiyong QIU Yafeng |
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| Affiliation: | (Shanghai Veterinary Research Institute,CAAS,Shanghai 200241,China) |
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| Abstract: | The Notch signaling and TLR signaling can interact cooperatively with each other to regulate the production of inflammatory factors and activate the macrophages.However,it is little known about how the Notch signaling regulates the inflammatory responses in porcine alveolar macrophages (PAMs).In this study,a model study was established in PAMs for inflammatory responses induced by LPS/TLR4 in order to investigate effect of LPS treatment on Notch signaling and regulation of LPS-induced inflammatory responses by Notch signaling.The results showed that LPS treatment increased the expression of ligands Jagged1,Jagged2 and Dll4,and up-regulated the expression of downstream target gene Hey1.Furthermore,the Notch signaling regulated LPS-induced inflammatory responses as demonstrated using DAPT treatment and silence RBP-J expression.These findings revealed that the Notch signaling in PAM regulated the LPS-induced inflammatory responses and paved the way for investigation of the Notch signaling in pig-associated bacterial infections. |
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| Keywords: | Notch signaling LPS porcine alveolar macrophages inflammatory cytokine |
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