Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming |
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Authors: | Benvenuti Federica Hugues Stephanie Walmsley Marita Ruf Sandra Fetler Luc Popoff Michel Tybulewicz Victor L J Amigorena Sebastian |
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Institution: | Unité INSERM 365, Institut Curie, 26 rue d'Ulm, 75005 Paris, France. |
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Abstract: | Upon maturation, dendritic cells (DCs) acquire the unique ability to activate na?ve T cells. We used time-lapse video microscopy and two-photon imaging of intact lymph nodes to show that after establishing initial contact between their dendrites and na?ve T lymphocytes, mature DCs migrate toward the contacted lymphocytes. Subsequently, the DCs tightly entrap the T cells within a complex net of membrane extensions. The Rho family guanosine triphosphatases Rac1 and Rac2 but not Rho itself control the formation of dendrites in mature DCs, their polarized short-range migration toward T cells, and T cell priming. |
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