| 巴喹普林的研究进展及其临床应用 |
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| 引用本文： | 郝智慧,孙伟之,赵永达. 巴喹普林的研究进展及其临床应用[J]. 安徽农业科学, 2013, 41(6): 2503-2504,2507 |
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| 作者姓名： | 郝智慧 孙伟之 赵永达 |
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| 作者单位： | 青岛农业大学化学与药学院,山东青岛266061;青岛康地恩药业股份有限公司,山东青岛;青岛康地恩药业股份有限公司,山东青岛266061;国家动物用保健品工程技术中心,山东青岛266111 |
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| 摘 要： | 巴喹普林是苄胺嘧啶类动物专用抗菌增效剂,具有广谱、活性高、消除缓慢的优点,其消除半衰期远优于甲氧苄胺嘧啶。在临床上巴喹普林与磺胺二甲基嘧啶等配成复方制剂,主要用于牛、猪、犬等动物感染性疾病的治疗,具有广阔的市场前景和研究价值。笔者对巴喹普林的抗菌活性、药动学特征、临床应用等进行了综述,旨在为该药的开发利用提供参考。
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| 关 键 词： | 巴喹普林 抗菌活性 药动学 临床应用 |
Research Advance of Baquiloprim and Clinical Application |
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| Affiliation: | HAO Zhi-hui et al(School of Chemistry and Pharmacy,Qingdao University of Agriculture,Qingdao,Shandong 266061) |
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| Abstract: | Baquiloprim（BQP）,as a noval veterinary amiopyrimidine antibacterial synerists,has the advantages of broad spectrum,high activity,and slow elimination.The antibacterial spectrum of BQP is similar to the spectrum of trimethoprim（TMP）,but the elimination half-life are much better.In clinic application,BQP is usually made compound preparations with sulfonamides,being used for the infectious diseases of cattle,pigs,dogs,etc.BQP has a good prospect in application and worths further studying.The antibacterial activity,pharmacokinetics and clinical application of BQP were summarized in order to provide reference for development and utilization of the BQP. |
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| Keywords: | Baquiloprim Antibacterial activity Pharmacokinetics Clinical application |
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