| Abstract: | [Objective]To investigate the lactation-promoting function of Yue-nai-tang decoction in female rats.[Methods]The newly delivered female rats were divided into 6 groups,blank control,low dosage group(125 mL/kg),moderate dosage group(250 mL/kg),high dosage group(500 mL/kg),pure rice wine group(250 mL/kg)and Muruduo granules as positive control group(9 g/kg).Each group contained8 female rats.Each fed 10 newborn rat pups to simulate the overload lactation model.Medication was lasted continuously for 21 days by intragastric administration.The growth status of rats was observed daily by recording the lactation of each female rat and body weight of cub.After medication,mammary gland of experimental rats was taken out for determining the mammary gland index and observing mammary sections.[Results]Both the lactation and body weight of rats in moderate dosage group and high dose group were remarkably higher than that in blank control,while did not vary significantly from positive control group.The mammary section observation found that the adenosis of mammary gland of female rats in middle and high dosage group(250,500 mL/kg)grew normally,with no difference from mammary gland of normal lactation rats,significantly superior to blank control and pure rice wine group,while not different from the positive group.[Conclusions]Yuenai-tang decoction can promote the lactation of newly delivered rats,thus facilitating the growth of mammary gland and cubs. |
