Sedative Effects of Intranasal Midazolam and Dexmedetomidine in 2 Species of Tortoises (Chelonoidis carbonaria and Geochelone platynota) |
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Affiliation: | 1. University of Tennessee College of Veterinary Medicine, Knoxville, TN USA;2. Department of Small Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, TN USA;3. Department of Biomedical and Diagnostic Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, TN USA.;1. Clinica per Animali Esotici, CVS, Via Sandro Giovannini 53, 00137 Roma, Italy;2. School of Veterinary Science, The University of Queensland, Gatton Campus, 4343 Gatton, Queensland, Australia;3. Department of Veterinary Medical Science, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia (BO), Italy;4. Department of Ultrasonography and Cardiology, CVS, Via Sandro Giovannini 53, 00137 Roma, Italy;5. Clinica Veterinaria Castellarano, via Fuori Ponte 1/1, 42014 Castellarano (RE), Italy. |
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Abstract: | The sedative effects of intranasal midazolam and dexmedetomidine were evaluated in 2 tortoise species as a means to facilitate handling and performing diagnostic procedures. Six red-footed tortoises (Chelonoidis carbonaria) and 6 Indian star tortoises (Geochelone platynota) received the following treatments in a randomized order with 2-week washout periods between the treatments: midazolam (0.5 and 1.5 mg/kg), dexmedetomidine (0.05 and 0.15 mg/kg), and saline control. Tortoises were evaluated and scored for sedation (using a previously published subjective method) by blinded observers, and results were averaged for each species and treatment group. Low-dose dexmedetomidine (0.05 mg/kg) in red-footed tortoises resulted in a significantly higher median sedation score at 5 minutes compared with other treatments. Control saline resulted in a higher median sedation score 5 minutes after administration in Indian star tortoises compared with red-footed tortoises. No other significant differences were observed between treatments or between species. The results suggest that intranasal administration of midazolam or dexmedetomidine, at the dosages used in this study, do not provide effective sedation in red-footed tortoises or Indian star tortoises, based on a subjective scoring system. |
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Keywords: | chelonians dexmedetomidine midazolam sedation tortoises |
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