| Abstract: | [Objective] to investigate the therapeutical effect of Chinese gallnut on psoriasis vulgaris and its mechanism. [Methods]Guinea pig auricular psoriasis model was established by 0. 5% propranolol emulsion and it was intervened by Gall ointment to observe the external form,pathologic changes and inflammatory cell infiltration of psoriasis. Baker scoring and inflammatory cell infiltration counting was conducted to evaluate the therapeutical effect of Gall ointment. Immunohistochemical method was used to detect the content of MVD in damaged skin of Guinea pigs' right ears and based on which to investigate the action mechanism of Chinese gallnut on psoriasis. [Results]Gall ointment could resolve the swelling in the back of the Guinea pig ear,reduce scales,improve angiotelectasis,lower pathologic histology score and reduce the number of cells in inflammatory cell infiltration; it could significantly lower the MVD value of damaged skin tissues in the model. [Conclusions] Gall ointment could improve the microcirculation of damaged skin tissues of psoriasis by reducing the MVD in the damaged skin,as a result,it could resist the proliferation of microvessel and it had therapeutical effect of psoriasis. |
