| Abstract: | [Objective] To screen the anti-inflammatory active fractions from RADIX ET RHIZOMA GENTIANAE.[Methods]Anti-inflammatory activity screening was carried out based on mice auricle swelling model induced by xylene,capillary permeability model in mice abdominal cavity induced by glacial acetic acid,rats footpad swelling model induced by carrageenan and PGE2 model in inflammatory tissues of rats swelling foot induced by carrageenan.[Results] Compared with Tween-80 group,high-and middle-dosage groups of water fractions( 6,3g/kg) had significant inhibitory effects on mice auricle swelling induced by xylene,capillary permeability in mice abdominal cavity induced by glacial acetic acid,rats footpad swelling induced by carrageenan,and PGE2 in inflammatory tissues of rats swelling foot induced by carrageenan( P 0.05,0.01).Other fractions showed weak or basically no activities.[Conclusions]Water fraction was the anti-inflammatory active fraction of RADIX ET RHIZOMA GENTIANAE. |
