| Abstract: | [Objective] To research the anti-bacterial effects in vitro of Jinweng Zhili Granules and its antipyretic and anti-inflammatory effects on animal. [Methods]Anti-bacterial effects of Jinweng Zhili Granules were detected by MIC method and drug sensitive test. A total of60 male Kunming mice were randomly divided into blank control group,aspirin group,low-dosage group of Jinweng Zhili Granules,middledosage group of Jinweng Zhili Granules,and high-dosage group of Jinweng Zhili Granules. Mice were given drugs by gavage for 7 d. Swelling degree of ear slice was calculated and the anti-inflammatory effects were analyzed. A total of 60 rabbits were randomly divided into high-dosage group of Jinweng Zhili Granules,middle-dosage group of Jinweng Zhili Granules,low-dosage group of Jinweng Zhili Granules,positive drug group,blank control group and model group. Endotoxin was administrated through the ear venous in order to establish febrile model. Effects of Jinweng Zhili Granules on the body temperature of febrile rabbits induced by endotoxin were analyzed. Blood was collected by heart blood collection method. When the plasma was separated,cA MP content in rabbits were detected. [Results] The MIC values to Escherichia coli,Staphylococcus aureus,Clostridium welchii,Salmonella typhimurium,Candida albicans were 3. 75,1. 875,15,7. 5 and 7. 5 mg / mL,respectively. The swelling degree of mice slice in model group reached 121. 7%. And the swelling degrees in high- and middle-dosage groups of Jinweng Zhili Granules were 55. 6% and 56. 2%,respectively,which had extremely significant differences with that of model group( P 0. 01).Jinweng Zhili Granules reduced the body temperature of febrile rabbits induced by endotoxin. The cA MP content in model group was 34. 13 pmol / mL; and the cA MP contents in high-and low-dosage groups were 24. 74 and 26. 61 pmol / mL,respectively,which had extremely significant differences compared with model group( P 0. 01). [Conclusions]Jinweng Zhili Granules had anti-bacteria,anti-inflammation and antipyretic effects. |
