Antiviral and antituberculous activity of Helichrysum melanacme constituents |
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Authors: | Lall N Hussein A A Meyer J J M |
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Affiliation: | Department of Botany, University of Pretoria, Pretoria 0002, South Africa. namrita@postino.up.ac.za |
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Abstract: | Bioassay guided fractionation of the acetonic extract of Helichrysum melanacme using human Influenza virus type A and a drug-sensitive strain of Mycobacterium tuberculosis in vitro resulted in the isolation of 2 4',6'-trihydroxy-3'-prenylchalcone (1) and 4',6',5'-trihydroxy-6',6'-dimethyldihydropyrano[2',3'-2',3'] chalcone (2) as active constituents. 3-O-methylquercetin and quercetin were also isolated but were inactive against the microorganisms tested in this study. |
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Keywords: | Helichrysum melanacme Influenza virus A Mycobacterium tuberculosis Chalcone derivatives |
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