The pharmacokinetic behaviour of marbofloxacin in Eurasian buzzards (Buteo buteo) after intraosseous administration |
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Authors: | Garcia-Montijano Marino Waxman Samanta Lucas J Julio de Luaces Inés Zalba Javier González Fernando Andrés Manuel I San Rodríguez Casilda |
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Institution: | AULAGA, Centro de Cria del Aguila Imperial, Ibérica Quintos de Mora, Ministerio de Medio Ambiente, Toledo, Spain. |
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Abstract: | This study reports on the administration of a single dose of marbofloxacin (2 mg/kg) to five adult Eurasian buzzards (Buteo buteo) by the intraosseous (IO) route, which has been proposed as a rapid and efficient means for the parenteral delivery of antimicrobial drugs. The drug was rapidly absorbed. Peak marbofloxacin concentration (C(max)) in plasma and area under the concentration-time curve (AUC) of 1.92+/-0.78 microg/mL and 8.53+/-2.73 microg h/mL, respectively. The time marbofloxacin remained in the plasma after IO administration was relatively short (elimination half-life, t(1/2beta)=4.91+/-0.65 h; mean residence time (MRT)=5.38+/-0.57 h). Single dose marbofloxacin gave values for C(max)/minimum inhibitory concentration (MIC) of 19.2 and an AUC/MIC value of 85.3h after IO administration. The IO route appears to be practical and effective for the rapid delivery of marbofloxacin to buzzards. |
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Keywords: | Intraosseous Buzzards Marbofloxacin Pharmacokinetic Bird |
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