Assessment of mechanical ventricular synchrony in Doberman Pinschers with dilated cardiomyopathy |
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Authors: | Jordi López-Alvarez LltVet MRCVS Sonja Fonfara Dr Med Vet MRCVS Brigite Pedro DVM MRCVS Hannah Stephenson BVMS MRCVS Peter J Cripps BSc BVSc MSc PhD MRCVS Joanna Dukes-McEwan BV MS MVM PhD MRCVS |
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Institution: | aSmall Animal Teaching Hospital, University of Liverpool, School of Veterinary Science, Leahurst, Chester High Road, Neston, CH64 7TE, UK;bDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Leahurst, Chester High Road, Neston, CH64 7TE, UK;cDepartment of Epidemiology and Population Health, University of Liverpool, School of Veterinary Science, Leahurst, Chester High Road, Neston, CH64 7TE, UK |
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Abstract: | ObjectivesLoss of temporal synchrony of myocardial contraction has been shown to reduce systolic function and be responsible for disease progression in people. The objective of this study is the assessment of inter- and intra ventricular synchrony in healthy Doberman Pinschers and those with dilated cardiomyopathy (DCM) by use of conventional Doppler and tissue velocity imaging.AnimalsA total of 60 scans from 35 client-owned Doberman Pinschers presented for cardiac evaluation were analysed.MethodsRetrospective analysis of data. Using the European Society of Veterinary Cardiology DCM taskforce scoring system, Doberman Pinschers were classified into 4 groups: Control (Group 1; n = 12), depressed systolic function other than DCM (Group 2; n = 9), preclinical DCM (Group 3; n = 8) and symptomatic DCM (Group 4; n = 6). The time intervals between the beginning of the QRS complex and the peak velocity of pulmonic flow (Q-P) and the peak aortic flow (Q-Ao) were used to assess global synchrony between both ventricles. The time intervals between the beginning of the QRS complex and the peak myocardial systolic velocity (Q-peak S) and the onset of myocardial systolic velocity (Q-start S) were measured at the base of the right and left ventricular free wall (RVFW and LVFW) and interventricular septum (IVS), and used to determine segmental longitudinal inter- and intra ventricular synchrony.ResultsNo significant loss of global or segmental longitudinal inter- or intra ventricular synchrony was identified between the groups.ConclusionImpairment of longitudinal fibre synchrony does not appear to be significantly associated with clinical status of DCM in Doberman Pinschers, although it was identified in certain individuals. |
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Keywords: | Canine Tissue Doppler imaging Electromechanical delay Ventricular synchrony Dyssynchrony |
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