猪繁殖与呼吸综合征病毒及疫苗的研究进展

猪繁殖与呼吸综合征（PRRS）严重危害养猪业的健康发展，每年给养猪业带来巨大的经济损失。猪繁殖与呼吸综合征病毒（PRRSV）是PRRS的致病因子，其可引起孕猪在妊娠后期出现早产、流产或死产等繁殖障碍，并可在新生仔猪引起呼吸系统症状。目前虽然已有商业化的灭活疫苗及减毒活疫苗，但它们的保护效果仍不理想。因此深入研究PRRSV的基因结构、蛋白功能、病毒的生物学性状及致病机制将有助于研发安全、有效的PRRS疫苗。作者对PRRSV及其疫苗的研究进展作一综述。

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus and its Vaccines

Porcine reproductive and respiratory syndrome (PRRS) severely affects prosperity of swine industry, and results in enormous economic losses every year. Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of PRRS. Pregnant sows infected with PRRSV may suffer from early farrow, abortion or stillbirth, and newborn piglets may develop respiratory symptoms. Although at present inactivated and live-attenuated PRRS vaccines are commercially available, their protective effects are not ideal. Therefore, study on PRRSV gene structure, protein functions, biological characteristics, and pathogenesis will facilitate research and development of safe and effective PRRS vaccines. This article will introduce research progress on PRRSV and its vaccines.