生长激素受体介导的信号转导机制研究进展

生长激素(growth hormone,GH)对动物的生长发育具有重要的生理作用.GH与生长激素受体(growth hormone receptor,GHR)结合后才会发挥一系列的生理作用.近年来,人们对GHR结构和功能的研究取得了巨大的进展,并取得了一些重大的突破.现在已清楚了GH-GHR轴激活一些相关的信号转导通路,但并非所有的通路都依赖酪氨酸激酶.作者从以下几个方面总结了GHR作用下的信号转导机制的研究进展:GHR的结构与功能;依赖JAK2的相关信号通路;不依赖JAK2的相关信号通路;GHR信号负调控因子.阐明这些复杂机制,对进一步了解GH对动物不同的生理和病理作用具有重要意义.

Research Progress on Signal Transduction Mechanisms Underlying Growth Hormone Receptor Action

Growth hormone (GH) has important physiological roles on animals in growth and development. GH plays a series of physiological effects after binding to growth hormone receptor (GHR). Our understanding of the mechanisms of action of GH and its receptor, the GHR, has advanced significantly in the last decade and has provided some important surprises. It is now clear that the GH-GHR axis activates a number of inter-related signalling pathways, not all of which are dependent on the intracellular tyrosine kinase, JAK2 as originally postulated. This paper summarizes the following aspects of signal transduction mechanisms progress under the GHR role:GHR structure and function;GHR signalling including JAK2-dependent signalling and JAK2-independent signalling; negative regulators of GHR signalling. Continued emphasis on elucidation of these complex mechanisms is critical to provide further insights into the animal diverse physiological and pathophysiological effects of GH.