| 伊维菌素微乳制剂的过敏性研究 |
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| 引用本文： | 邢守叶,周绪正,李冰,牛建荣,魏小娟,张继瑜. 伊维菌素微乳制剂的过敏性研究[J]. 中国畜牧兽医, 2014, 41(11): 275-278 |
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| 作者姓名： | 邢守叶 周绪正 李冰 牛建荣 魏小娟 张继瑜 |
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| 作者单位： | 1. 中国农业科学院兰州畜牧与兽药研究所, 农业部兽用药物创制重点实验室, 甘肃兰州 730070;2. 甘肃农业大学动物医学院, 甘肃兰州 730050 |
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| 基金项目： | 国家现代农业肉牛牦牛产业技术体系建设专项资金(CARS-38);重点牧区生产生态生活保障技术集成与示范(2012BAD13BOO)。 |
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| 摘 要： | 本试验旨在观察伊维菌素微乳制剂对动物的过敏性反应。以《化学药物刺激性、过敏性和溶血性研究技术指导原则》为指导,选用豚鼠及Wistar大鼠为试验动物,采用全身主动过敏试验和被动皮肤过敏试验观察伊维菌素微乳制剂对动物的致敏作用。结果显示伊维菌素微乳制剂对豚鼠和Wistar大鼠的过敏性反应均为阴性。本试验为伊维菌素微乳制剂的安全性评价提供了试验依据。
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| 关 键 词： | 伊维菌素微乳制剂 豚鼠 大鼠 过敏性试验 |
| 收稿时间： | 2014-06-27 |
Allergic Study of Ivermectin Microemulsion |
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| XING Shou-ye,ZHOU Xu-zheng,LI Bing,NIU Jian-rong,WEI Xiao-juan,ZHANG Ji-yu. Allergic Study of Ivermectin Microemulsion[J]. China Animal Husbandry & Veterinary Medicine, 2014, 41(11): 275-278 |
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| Authors: | XING Shou-ye ZHOU Xu-zheng LI Bing NIU Jian-rong WEI Xiao-juan ZHANG Ji-yu |
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| Affiliation: | 1.Key Laboratory of New Animal Drug Discovery, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730070, China;2. College of Veterinary Medicine, Gausu Agricultural University, Lanzhou 730050, China |
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| Abstract: | The study was aimed to observe the allergic reaction of ivermectin microemulsion injection on animals. Active systemic allergy test and passive cutaneous anaphylaxis test were carried out to study the allergic reaction of ivermectin microemulsion injection on Wistar rat and guinea pig, respectively, according to . The results showed that the allergic reaction of ivermectin microemulsion injection on Wistar rat and guinea pig were both negative. The study provided experiment evidences for the safety evaluation of ivermectin microemulsion. |
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| Keywords: | ivermectin microemulsion guinea pig rat allergic test |
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