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Effects of peripheral-type benzodiazepine receptors in platelet membrane on patients with depression after first attack of cerebral infarction
Authors:CHEN Yuan  CHEN Chun-fu  LI Cong-cong  XIAO Xiao
Institution:Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Abstract:AIM:To evaluate the changes of peripheral-type benzodiazepine receptors (PBRs) in platelet membrane in post-stroke depression (PSD) patients and to investigate the effects of PBRs on PSD. METHODS:Forty-three patients with PSD, fifty-nine patients with first-ever cerebral infarction and fifty-six healthy volunteers participated in this study. Platelet membrane in venous blood was prepared. Binding assay of the radioactive PBRs antagonist [3H]PK11195 to platelet membrane was performed. RESULTS:A significant difference of [3H]PK11195 binding was found among the 3 groups (P<0.01). Compared with the healthy volunteers [(298.2±25.1) pmol/(g protein)], a highly significant increase in [3H]PK11195 binding was observed in platelet membrane in the patients with first attack of cerebral infarction [(1 410.8±41.4) pmol/(g protein), P<0.01]. Compared with the patients with first attack of cerebral infarction, a significant reduction in [3H]PK11195 binding was detected in platelet membrane in the patients with PSD [(361.7±30.6) pmol/(g protein), P<0.01]. In the patients with PSD, no significant difference of [3H]PK11195 binding was found between men and women (P>0.05). [3H]PK11195 binding was related to the score of Hamilton depression rating scale (r=-0.44, P<0.01) but not to the duration of cerebral infarction (r=0.27,P>0.05). CONCLUSION:PBRs binding activity in platelet membrane decreases in the patients with PSD and affects the degree of depression.
Keywords:Post-stroke depression  Cerebral infarction  Peripheral-type benzodiazepine receptors  Blood platelets  
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