African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes |
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| Authors: | Ke Y Su B Song X Lu D Chen L Li H Qi C Marzuki S Deka R Underhill P Xiao C Shriver M Lell J Wallace D Wells R S Seielstad M Oefner P Zhu D Jin J Huang W Chakraborty R Chen Z Jin L |
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| Affiliation: | State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, China. |
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| Abstract: | To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia. |
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