Metabolites with Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Diaporthe sp. QYM12 |
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| Authors: | Yan Chen Ge Zou Wencong Yang Yingying Zhao Qi Tan Lin Chen Jinmei Wang Changyang Ma Wenyi Kang Zhigang She |
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| Institution: | 1.National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China; (Y.C.); (Y.Z.); (J.W.); (C.M.);2.School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China; (G.Z.); (W.Y.); (Q.T.);3.Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou 450063, China; |
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| Abstract: | One new diterpenoid, diaporpenoid A (1), two new sesquiterpenoids, diaporpenoids B–C (2,3) and three new α-pyrone derivatives, diaporpyrones A–C (4–6) were isolated from an MeOH extract obtained from cultures of the mangrove endophytic fungus Diaporthe sp. QYM12. Their structures were elucidated by extensive analysis of spectroscopic data. The absolute configurations were determined by electronic circular dichroism (ECD) calculations and a comparison of the specific rotation. Compound 1 had an unusual 5/10/5-fused tricyclic ring system. Compounds 1 and 4 showed potent anti-inflammatory activities by inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW264.7 cells with IC50 values of 21.5 and 12.5 μM, respectively. |
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| Keywords: | mangrove endophytic fungus Diaporthe sp anti-inflammatory activity |
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